Stereospecificity of retinol saturase: absolute configuration, synthesis, and biological evaluation of dihydroretinoids.

Biological Evaluation of Dihydroretinoids Alexander R. Moise,*,† Marta Domı́nguez,‡ Susana Alvarez,‡ Rosana Alvarez,‡ Michael Schupp,§ Ana G. Cristancho,‡ Philip D. Kiser,† Angel R. de Lera,‡ Mitchell A. Lazar,§ and Krzysztof Palczewski† Department of Pharmacology, Case School of Medicine, Case Western ReserVe UniVersity, CleVeland, Ohio 44106-4965, Departamento de Quı́mica Orgánica, Facultad de Quı́mica, UniVersidade de Vigo, 36310 Vigo, Spain, and DiVision of Endocrinology, Diabetes, and Metabolism, Department of Medicine and Department of Genetics, and The Institute for Diabetes, Obesity, and Metabolism, UniVersity of PennsylVania School of Medicine, Philadelphia, PennsylVania 19104